I've coated a lot of wood. I've never seen any appreciable swelling. Nothing that I've noticed anyway. I've fit things pretty tight sometimes. You can get some raising of the grain on the initial epoxy coat on some plywoods, but you can knock that down in a couple of minutes with some 120 grit paper. If I were the OP, I'd apply three fairly thin coats around the door frame, paying particular attention to the end grain. Apply each coat before the prior coat has fully cured. Once the third and last coat is past the tacky stage you can apply some sealer (I'd use clear silicone) and install the door frame. Pay special attention to the screws that attach the frame. I like to pre-drill the holes and dip each screw in a 1 oz. mixing cup with some silicone in it. You're going to leave a little play for the sealer anyway, right? You'll be fine. Just asking the question shows that you're taking more care with the installation than 99.9% of commercial contractors.